Andrew D. Weinberg, PhD
Earle A. Chiles Research Institute
Providence Cancer Institute
Dr. Weinberg is an experienced scientist with a background in biochemistry and immunology. Currently, he leads the Basic Immunology Laboratory at the Earle A. Chiles Research Institute, a Providence Center of Excellence for immuno-oncology and cellular therapy.
Dr. Weinberg’s previous work involves the TNF-receptor OX40. Together with his clinical colleagues at Providence, he launched a first-in-human phase 1 clinical trial of an OX40 monoclonal antibody. Pharmaceutical companies quickly added anti-OX40 agents to their development pipelines in response to Dr. Weinberg’s research efforts.
In 2017, Dr. Weinberg received the Judith Ann Hartmann Endowed Chair for the Laboratory of Basic Immunology in recognition of his efforts in translational cancer therapy. Along with leading the lLab at Providence, he is an adjunct professor for microbiology and immunology at the Oregon Health & Science University School of Medicine.
The goal of the Basic Immunology Lab is to understand the biology of the immune system in the context of cancer. The lab has focused on the immunostimulatory protein OX40 and how this molecule can be used as an immunotherapy.
Recently the lab contributed to the discovery of a novel subset of CD8+ T-cells from tumors, which are highly enriched for cells that can recognize and destroy cancer. Understanding the presence, role and dynamics of this T-cell population in different tumors has been instrumental to the development of adoptive T-cell therapy approaches and will help improve our understanding of how cancer immunotherapies work.
- Postdoctoral, Biology, University of California San Diego, 1990
- Doctor of Philosophy, Biochemistry, Washington State University, 1987
- Master of Science, Biochemistry, Washington State University, 1986
- Bachelor of Arts, Biochemistry and Molecular Biology, University of California at Santa Barbara, 1981
- President and CSO, AgonOx, Inc., 2012-present
- Managing member, AgonOx WMT, LLC., 2008-present
- Member, Basic Immunology Laboratory, Earle A. Chiles Research Institute, Providence Cancer Institute, 1995-present
- Adjunct professor, Microbiology and Immunology, School of Medicine, Oregon Health & Science University, 1990-present
- Research immunologist, Neuroimmunology, Veteran’s Affairs (VA) Portland Health Care System, 1990-1995
- Postdoctoral fellow, Department of Biology, University of California San Diego, 1987-1990
- Research assistant, Program in Biochemistry/Biophysics, Washington State University, 1982-1987
- American Association of Immunologists
- National Institutes of Health, Cancer Immunopathology and Immunotherapy Study Section
- OHSU Knight Cancer Institute
- Society for Immunotherapy of Cancer
- Society for Cancer Immunotherapy Team Science Award, 2020
- Judith A. Hartmann Endowed Chair for the Laboratory of Basic Immunology, 2017
Dr. Weinberg’s research is published in peer-reviewed scientific and medical journals. He has partnered with colleagues on various research projects, including projects funded by the National Institutes of Health.